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It is composed of the tripeptide glycylLhistidylLlysine bound to a divalent copper ion, forming a highaffinity chelated structure that enables controlled copper handling within biological environments

This has led to the development of GLP-1 receptor agonists (GLP-1 RAs), which have demonstrated favourable effects not only on metabolic variables but also on cardiovascular endpoints [4,5,6]

A key pathological mechanism linking obesity to metabolic complications is insulin resistance (IR), a reduced biological response to insulin in target tissuesprimarily skeletal muscle, liver, and WAT [7]

European Academy of Andrology Guideline Management of oligo-astheno-teratozoospermia