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FIGURE 9 The core of this toxicity mechanism lies in the depletion of the labile Fe 2+ pool (Figure 5B)without altering total cellular iron (Figure 5A)which triggers a compensatory iron-starvation response (IREB2, TfR1, Ferritin

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The symptoms of neuralgia vary in intensity and nature over time, but they can develop into severe pain, loss of muscle control, and life-threatening complications

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