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Prior to the surgical procedure, informed consent was obtained from each patient, and the use of samples for this research was approved by The Medical Ethics Committee of The First Affiliated Hospital of the University of Science and Technology of China

Also, the 3D crystallographic structure of tyrosinase from Agaricus bisporus mushroom with a tropolone inhibitor (PDB ID: 2Y9X) 37 was downloaded from the RCSB protein database ( 38