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Its a glucagon-like peptide 1 receptor agonist (GLP-1 RA)

After 68 weeks of semaglutide injections, the average patient lost more than 15% of their body weight, but within 12 months of treatment ending, patients regained two thirds of their prior weight loss on average

As well, semaglutide needs to be taken with care when paired with other medications such as insulin, metformin, antidepressants, and diuretics

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Markers to watch include: Vitamin B12 levels may decrease over time, especially in people with reduced dietary intake or those combining semaglutide with metformin (which independently reduces B12 absorption)