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Most doctors currently recommend injectable tirzepatide as the primary option because of its extensive clinical evidence

Similar content being viewed by others Introduction The connection between diabetes and mental health is becoming increasingly apparent

In the PIONEER 1 trial, oral semaglutide 14mg as monotherapy reduced A1C by approximately 1.5% at 26 weeks, with progressive improvement reaching up to 1.8% in some analyses

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The review contextualised native GLP-1 as the reference molecule for the entire dual GIP/GLP-1 receptor agonist research field including tirzepatide (approved) and novel triple agonists targeting GLP-1R, GIPR, and GCGR simultaneously confirming native GLP-1s ongoing research importance as the pharmacological anchor of this rapidly expanding compound class