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The visceral adipose tissue of insulin-resistant vs insulin-sensitive obese patients shows marked differences in the DNA methylation landscape, with the most relevant changes observed at the promoter of genes involved in adiposity, diabetes development, chronic inflammation and aging such as COL9A1, CD44, IGF2BP1, ADAM2, TET1, ZNF714, ADCY9, TBX5, and HDACM [127]

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Biological synthesis requires more development time to set up the strains and scale