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To this end, there has been an increasing shift from using the gold standard endpoint of overall survival (OS) (see Sidebar 28 ), to earlier endpoints like progression free survival, overall response rate, and duration of response to achieve an accelerated approval designation from FDA

James the light peppery characteristic enjoyed by so many pipe smokers

Falcon Pipes occupies a distinctive niche with its patented aluminum alloy pipe system, which has retained a loyal following since its introduction in the 1930s due to the practical advantages of its interchangeable, easy-to-clean design

The material consist of a Facilitator's Guide, 7 PowerPoint presentations (with notes to guide the presentation), exercises to be used during the workshop and a final evaluation form

A vintage Chinese smoking pipe also known as Yen Tsiang, smoking pistol, that was used for opium