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Engages brainstem and hypothalamic circuits (notably in the area postrema and related nuclei) to decrease food intake, increase satiety, slow gastric emptying, and ultimately lower body weight in animal and human studies

Recently, it was revealed that circulating/hepatic IGF-1 levels presented a circadian rhythm in mouse fed ad libitum

10.1016/j.nantod.2024.102323 38 Chiorcea-PaquimA.-M

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and a clinical study in 180 type 2 diabetics showed that bilberry, in combination with several other micronutrients, improved measures of ocular health and visual acuity in subjects with preclinical or early diabetic retinopathy (Moshetova 2015)