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But to move from hypothesis to proven treatment, he says, the scientific community urgently needs double-blind, randomized, controlled trialsthe gold standard for treatment researchon nicotine therapy for post-acute infection syndromes

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Population studies cannot tell us whether nicotine itself caused the observed association, whether some other tobacco-related chemical mattered, or whether the finding was partly shaped by who seeks medical care, who receives a diagnosis, and who gets counted in the first place

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