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Currently, 37 kinds of spirostanol compounds have been discovered, and mostly reported RPS in the research are spirostanol, including polyphyllin I (also named polyphyllin D), polyphyllin II, polyphyllin III, polyphyllin VI, polyphyllin VII, polyphyllin C, and polyphyllin H [29,30] (Fig

IL-2 induces and stabilizes the main transcription factors Forkhead box protein P3 (Foxp3) by activating the signal transducer and activator of transcription 5 (STAT5) pathway[23].The core of the Th17/Treg balance lies in the reciprocal antagonism between RORt and Foxp3 [24].Under conditions of conflicting cytokine signals, RORt and Foxp3 can be coexpressed in nave CD4 + T cells

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Hydroperoxide metabolism in mammalian organs

Schulte-Oehlmann, U