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10.3109/03602532.2011.552910 Drug Metab

In addition, cytochrome P450 oxygenases (CYP450) in the ER of the liver, lung, and small intestine are also the production sites [49, 50]

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However, since NO is freely diffusible across membranes, it is possible that the mitochondrial production of peroxynitrite may derive from extramitochondrial NO diffusing into mitochondria to react with superoxide generated by ETC

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