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10.1142/S0192415X98000397 [DOI] [PubMed] [Google Scholar] Cutler R

Many of these are contraindicated and can severely hurt you when used in conjunction with anesthesia, other medications, or while undergoing surgery

the pH of a solution prepared from the water-soluble composition or a peptide salt of the present invention should be such that said pH will not exert any adverse influence upon the activity of the pharmacologically active peptide, but is within an acceptable range for injections in general and further, such that said pH will neither cause a great change in viscosity of the solution nor allow formation of a precipitate or the like

10.1038/361362a0 100

This 3% reduction is calculated to have a total possible impact of up to $12 billion dollars