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According to the World Health Organization , obesity has almost tripled since 1975 and has been a major contributor to numerous health diseases

HIV leads to the dysregulated binding of CCL2 to its receptor, C-C motif chemokine receptor 2 (CCR2), on neurons, astrocytes, and brain microvascular endothelial cells, ultimately leading to the increased permeability of the bloodbrain barrier (BBB) [51]

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Scirica BM, Bhatt DL, Braunwald E, Steg PG, Davidson J, Hirshberg B, Ohman P, Frederich R, Wiviott SD, Hoffman EB, Cavender MA, Udell JA, Desai NR, Mosenzon O, McGuire DK, Ray KK, Leiter LA, Raz I, Committee S-TS, and Investigators

Serum Bilirubin Levels in Overweight and Obese Individuals: The Importance of Anti-Inflammatory and Antioxidant Responses