(Published) Peterson, J., Schubert, D., Campbell, J., Bemben, M., and Black, C
In summary, impaired prefrontal cortical function in elevated mood states may result in compromised regulation of limbic and paralimbic areas, manifesting as excessive emotional reactivity, irritability, impulsivity, difficulty conforming emotional responses to the social milieu, excessive indulgence of appetitive drives, and cognitive/attentional impairment
The experience of tiredness can vary considerably between individualssome may notice mild lethargy during the initial weeks of treatment, whilst others may experience more persistent symptoms that affect daily functioning
Active monitoring is what turns a manageable combination into a safe one
PMID: 11101503)