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It may begin in childhood, but also affects adults, with females twice as likely to be afflicted

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The same group measured intracellular glutathione ratios, oxidant species generation, and activation of nuclear factor erythroid-related factor 2 (Nrf2)-controlled antioxidant response elements and did not detect oxidative stress in human bronchial epithelial cells exposed to e-cigarette aerosol extracts, whereas significant oxidative stress was found in cultures exposed to cigarette smoke [17]