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First-line medications in the UK include: Methylphenidate (e.g., Concerta XL, Equasym XL, Medikinet XL)a stimulant that increases dopamine and noradrenaline availability Lisdexamfetamine (Elvanse)a prodrug stimulant for ADHD when significant impairment persists [19] [18] Atomoxetine (Strattera)a non-stimulant noradrenaline reuptake inhibitor, suitable when stimulants are contraindicated or ineffective Guanfacine (Intuniv)a non-stimulant alpha-2 adrenergic agonist licensed for children and adolescents aged 6-17 years Medication choice depends on individual factors including comorbidities (such as anxiety, tics, or substance misuse history), cardiovascular health, and patient preference

10.1007/s00415-024-12380-7 265 WangX.SongR.LuW.LiuZ.WangL.ZhuX.et al (2017b)

Updated April 1, 2025