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Endpoint Assessment: Lipolysis: Glycerol and fatty acid release Gene expression: Lipid metabolism enzymes Body composition: Fat and lean mass Metabolic parameters: Without glucose/IGF-1 changes Mechanism Investigation: Key research questions: What is the molecular target of AOD9604

Start gentle ROM (Week 1) gentle stretching (Weeks 2-4) progressive low-load strengthening (Weeks 2-4) Progress to resistance under PT supervision (Weeks 4-6) Follow structured protocol rather than self-directed progression Increase intensity/duration by no more than 10-15% per week What Should You Do If Symptoms Return After Activity