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In addition, the GYTS is a widely supported WHO survey that has a globally standardized methodology that builds representative, independent, and cross-sectional samples, allowing comparison of the state of population health over time and with respect to other countries where it is also used 25

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Importantly, EC-induced oral dysbiosis disrupts microbial homeostasis, fostering pathogenic proliferation and metabolic alterations that contribute to a spectrum of oral pathologies, including periodontitis and oral carcinogenesis

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