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J Clin Invest 115(12):34943505

GLP-1 receptor agonists are hydrophilic proteins with molecular weights exceeding 3,000 Daltonsfar above the typical 500 Da threshold for effective passive skin penetration

There were 33 peptides in total with the format VYDVRQ x YV (p7 library) or VYDVRQA x V (p8 library)

On the other hand, tourniquet pain induced by intravenous regional anesthesia (IVRA) is also related to peripheral nerve injuries, of which the mechanism may be nerve ischemia and compression [152, 153]