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It is consumed by placing a pouch of powdered tobacco leaves under the lip for nicotine to be absorbed through the oral mucosa

Table 9: Number of Patients with Clinically Significant or Serious NPS Adverse Events by Treatment Group Among Patients without a History of Psychiatric Disorder As shown in Table 10, there were more clinically significant NPS adverse events reported in patients in the psychiatric cohort in each treatment group compared with the non-psychiatric cohort (Table 9)

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