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Kinetic data of the herein presented jr PPO1 mutant Leu244Arg demonstrate that Arg at the 2 nd activity controller position does not convert a TYR into a CO either

However, despite encouraging early laboratory findings, its clinical development was discontinued in 2007 after failing to demonstrate significant weight-loss efficacy in large-scale human trials

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Inhibitors of chitin biosynthesis Chitin is a homopolymer composed of an N -acetylglucosamine monomer conjugated by -1,4-glycosidic linkages