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INTRODUCTION Chronic kidney disease (CKD) is a pressing public health concern in developed and developing nations, with approximately 700 million new cases diagnosed annually 1

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Although rather few patients stopped smoking post diagnosis, and the ability to assess benefits of smoking cessation was limited, our finding is in accordance with previous studies.68 A reduction of systemic inflammation and oxidative stress following smoking cessation may contribute to the favourable effect on disease outcomes.2830 Although we found a significant influence of current smoking on the risk of cognitive disability worsening in MS as well as a trend showing increased risk of unfavourable outcome with increasing cumulative dose of smoking, we observed no significant association in our main analysis where individuals were followed up to 15 years

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