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Chronic LC exposure decreases CFTR protein levels and decreases ASL height to a greater extent than cigarettes We and others have previously shown that acute and chronic cigarette smoke exposures decrease CFTR protein levels in vivo and in vitro , leading to a reduction in ASL volume in HBECs 9,11

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5.1 Mitophagy and COPD Exposure to CS is a major risk factor for COPD, and long-term exposure to CS damages bronchial epithelial cells via multiple mechanisms

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