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Possible mechanism of the impact of smoking on microbiome Massive studies demonstrated the adverse health impacts of tobacco on systemic pathophysiologic changes that can lead to disease, were associated with the chemicals, heavy metals, particulate matter and other constituents in tobacco [19,20,21,22,23,24,25,26,27]
it is well established that 80-90% of lung cancers occur in patients with a history of smoking
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