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Por accin de la enzima trimetil lisina dioxigenasa (TML-DO, EC 1.14.11.8) se hidroxila la posicin 3 de la TML para formar la 3-hidroxi- N 6 , N 6 -trimetil lisina ( HTML ) en presencia de oxgeno diatmico como agente oxidante, -cetoglutarato como aceptor de electrones, adems de hierro (II) y cido ascrbico como cofactores
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While the kinetic rate constants could not be accurately determined for GLP-1 QMP, GLP-1 QMP/LX (0.2 nM) showed an almost 600-fold higher binding affinity compared to GLP-1 WT (Fig
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