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In a similar way as MOR, DOR phosphorylation of the Y318, located in the NPXXY motif, occurred upon DTLET ([D-Thr 2 -Leu 5 -Thr 6 ]enkephalin) exposure in a Src dependent manner (Kramer et al., 2000a,b)

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3.2.1 Resistance to Peptidase Degradation The presence of the acetyl group alters the molecules spatial conformation, thereby making SAG highly resistant to gastrointestinal peptidases