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This was demonstrated by the finding that deficiency of alternative complement pathway (using CFB - / - mice) can ameliorate age-related macular degeneration (AMD) associated with smoking ( Complementcoagulation interplay under smoke and vape exposure Evidence has demonstrated that the complement and coagulation systems/cascades do not operate in isolation

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Numerous other conditions are related to smoking, including pulmonary hypertension (PH), a rare but severe disease characterized by high blood pressure in the lungs

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