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The primary outcome studied across all the trials was the first occurrence of death from cardiovascular causes, nonfatal myocardial infarction, or nonfatal stroke
have anti-inflammatory, anti-ischemic and anti-fibrotic effects and inhibit myocardiocyte apoptosis.29,32,42 More recently, it has been reported that they also reduce epicardial fat.43 They also inhibit platelet aggregation and thrombosis.44 In the lungs, rGLP-1 activation conferred protection against lipopolysaccharide-induced acute lung injury.45 In adipose tissue they favor adipocyte differentiation, decreases lipid deposition in white fat and facilitate its conversion to brown fat, as well as thermogenesis and energy consumption29,32,4648
The effectiveness of Dula at 50, 100, and 150 g/kg on the colons histological alterations Figure 3 illustrates normal colonic mucosal glands that are average in size and form and surrounded by goblet and columnar cells of H&E-dyed colon layers from the Dula control and normal colon which showed a fibroblastic matrix that had been split into smaller sections by individual fibroblasts (Fig
However, translating these natural products into clinical use faces challenges such as inadequate standardization, low in vivo exposure, and insufficient safety evidence
