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In a Phase 2 obesity study published in a leading medical journal in 2023, retatrutide was associated with marked, dose-dependent reductions in body weight over 48 weeks

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Comprehensive review of the hormone GLP-1 including its effects on multiple aspects of human health and the use of GLP-1 R agonists in type 2 diabetes and obesity

GLP-1 receptor activation enhances glucose-dependent insulin secretion, suppresses inappropriate glucagon release, slows gastric emptying, and reduces appetite through central nervous system effects