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NNMT upregulation also elevates homocysteine levels, activating pro-inflammatory and pro-oxidative cascades (TLR4-NF-B and STAT3-IL-1 pathways) linked to atherosclerosis, heart failure, and coronary heart disease

Intracellular iron overload and accumulation of lipid peroxides are the characteristics of ferroptosis, so ferroptosis is considered as one of the potential mechanisms of delayed wound healing in diabetics [136, 137]

Melatonin as a regulator of fruit crop development and stress response

Normality assumption was examined prior to analysis and data were log transformed when appropriate to ensure normality of distribution