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In the case of naltrexone-bupropion, bupropion is known for its use as a single agent for depression and for smoking cessation and has been found to promote weight loss at 300 or 400 mg daily

Native, unmodified peptides are typically cleaved rapidly by serum dipeptidyl peptidase-4 (DPP-4), neutral endopeptidase, and aminopeptidases

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Dee KC, Rueger DC, Andersen TT, Bizios R

Inadequate B12 levels can lead to impaired red blood cell formation, resulting in megaloblastic anemia, a condition characterized by fatigue and weakness