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[9] The World Health Organization estimates that, annually, more than 7 million people die from tobacco-related causes, including 1 } : CS1 maint: DOI inactive as of July 2026 (link) Endocrine

In laboratory assessments (e.g., cold pressor test), minimally-deprived or abstinent smokers, compared with nonsmokers, exhibit lower pain tolerance and report greater subjective experiences of pain where such pain reports positively correlate with nicotine withdrawal severity [9294]

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Participants who quit smoking had significantly greater reductions in V S /f P across regions than non-quitters, and correlations were found between reductions in cigarettes per day and decreases in V S /f P for brainstem and cerebellum, but there was no between-group effect of treatment type