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Patients and methods Patients One hundred and forty-six pediatric patients, referred between May 2003 and May 2018 to the Genoa Pediatric Kidney Transplant Program for first allografting, were considered for this study

"In the case of fermentation-based active substances, which consist of more than one active moiety, the impurity profile is usually very complex and the thresholds in the ICH Q3A and Q3B cannot be considered applicable," said Xellia