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By 6 months, clinical trial participants using semaglutide typically achieve 15-25 pounds of weight loss

For most individuals, this is unlikely to pose problems, but those with compromised immune systems or autoimmune conditions should exercise additional caution and seek medical advice

doi: 10.1163/156856208784909435

However, since these receptors mediate the diverse biologic actions of more than a dozen ligands 23,24,25 , there are potential concerns with broad ActRIIA/B blockade as an approach to maintain or increase muscle growth

There have been reports of gallbladder disease , including cholelithiasis (gallstones) and cholecystitis, possibly related to rapid weight loss