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However, notably in a PCP model of schizophrenia, only 30 mg/kg, but not 3 or 10 mg/kg, rescued defects in hyperlocomotion and PPI, in stark contrast to cell culture models where lower models were more beneficial ( in vivo (Table 2)

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This oxidation can proceed via a one-electron oxidation of dopamine to form a dopamine o -semiquinone radical (reaction 1), which is subsequently oxidized to dopamine o -quinone (reaction 2) by reducing two molecules of oxygen to superoxide radicals

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