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Smokeless Tobacco can cause mouth cancer, gum disease and tooth loss

[20] Systematic tobacco use dates back to as early as 50003000 BC when the agricultural product began to be cultivated in Mesoamerica and South America

Retrieved 22 February 2009

A large Korean study published in 2021 examined the effects of quitting smoking, reducing smoking by 50% or more, reducing smoking by 2050%, sustaining the same level of smoking, or increasing smoking on a persons risk of cardiovascular disease (stroke and heart attack)

45 Taken together, these studies show the substantial benefits of quitting for heart and general health, with even very light smoking increasing a persons risk of angina, heart attack or stroke