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Although PPV was considered an attractive strategy for PCa, and even after successful phase II trials, the phase III trial of 310 patients with mCRPC receiving docetaxel found no survival advantage over PBO (HR 1.04

Give the patient a drink with a radioactively labeled B12

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Runs were performed under the following conditions: 2 min at 25% B, then a linear gradient to 95% B in 26 min, followed by a 4-min purge step at 95% B and by a 8-min re-equilibration step to the starting conditions