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Animal experiments After a 1-week acclimatization period, male C57BL/6 mice were orally gavaged with 150 mg/kg of metformin

doi: 10.1097/TA.0000000000003945 146 TranHCMMbembaEMourotNFaltasBRousseauALefkouEet al

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The compound has been shown in cell-based research to upregulate VEGFR2 transcript levels, increase phosphorylation of downstream signalling intermediates after VEGF stimulation, and enhance endothelial tube formation in matrigel assays