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Acutely increasing the tonic activity of VTA DA neurons using optogenetics is sufficient to mimic the behavioral bias (decreased exploration) induced by nicotine, suggesting that the DA control of the exploration/exploitation balance is altered by long-term nicotine exposure

He started laughing, and he leans forward, he goes, Now, well, Michael, I already have another actor to be Doc Holliday, and yknow, its not gonna happen. I go, Well who is it? He goes, Oh its Dennis Quaid. I started to get up and he goes, How about Virgil

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