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The regulatory environment is so favourable that an anti-smoking advocacy group once dubbed Indonesia the "tobacco industry's Disneyland"

Patients frequently require several attempts before successfully quitting

Over time, the brain becomes accustomed to the presence of nicotine and adjusts its functioning accordingly

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In this regard, ROS appears to be a plausible candidate of this stimulant because CS contains high concentrations of free radicals, radical precursors, and long-lived metastable radical intermediates, all of which may generate ROS (Pryor, 1992)