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By regulating the pool of available actin monomers, TB4 and by extension the TB-500 fragment is thought to enhance the ability of cells such as endothelial cells, keratinocytes, and fibroblasts to migrate toward and repopulate a wound

As for systemic oral bioavailability - whether enough of it crosses from the gut into circulation to affect other tissues - that has not been definitively established in published human research

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So I very much try to avoid, want to avoid, and usually can periods of estrogen deprivation from my patients