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Anyone with active or prior cancer, pituitary disease, diabetic retinopathy, severe kidney disease, or pregnancy should not use GH-stimulating peptides

People using oral contraception should either: Switch to a non-oral method, or Use a barrier method for 4 weeks after initiation and 4 weeks after each dose escalation Given the titration schedule, that can mean several months of backup contraception

This can include paying close attention to factors like nutrition, activity, sleep, and stress

A carbon chain divided allows the nonpolar effect to be reduced, which leads to increased water solubility