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Similar data in direct connection with OS were also observed in the case of other sweeteners such as saccharin, sucralose, and cyclamate, with a similar effect on the level of peroxidized lipids, GSH, but also on 8-hydroxy-20-deoxyguanosine (8-OHdG), without describing a clear mechanism of ROS generation [152,153,154,155]

Taking together all the studies discussed in this review, it seems reasonable to conclude that NRF2 is part of the sleep biochemical regulatory network

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