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For instance, individuals with T2D already present with the dyslipidemic feature which is normally characterised by the highly accumulation of lipids and these can easily be attached by free radicals to generate damaging oxidative products (Ito et al., 2019)

Instead of wear and tear, the immune system mistakenly attacks joint tissues, leading to persistent inflammation, swelling, and structural damage

In addition, obesity could inhibit hepatic utilization of BCAAs and cause the inactivation of BCKDH by increasing the ratio of BCKDK (BCKDH kinase)/PPM1K (BCKDH dephosphorylase) in hepatocytes

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Clinical trials would need an IND protocol