Resveratrol hinders the PI3K/Akt/mTOR & Wnt/-catenin pathways, which result in cell cycle arrest and apoptosis, and activates SIRT1, a NAD+-dependent deacetylase, which impacts histone acetylation and p53 actions
van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, Ritchie W, Feng Y, Bailey CG, Deng N, Harvey K, Beith JM, Selinger CI, O'Toole SA, Rasko JE, Holst J
Gao et al., 2022)
scar tissue formation at the injury site Anti-inflammatory down-regulates NF-B signaling, one of the key inflammatory pathways active in disc herniations Works in synergy with BPC-157 while BPC-157 creates the growth signals, TB-500 provides the cellular migration framework to execute the repair Protocol: Loading phase: 2.5mg5mg/week subcutaneous injection for 46 weeks Maintenance: 1.252.5mg/week ongoing Frequency: Single weekly injection or split into two 1.25mg injections across the week (both approaches work) The Synergy: Why Run Both Together BPC-157 and TB-500 work through different but complementary mechanisms
Research spanning three decades has mapped how this 15-amino acid peptide interacts with vascular tissue, revealing mechanisms that extend well beyond its better-known healing properties
