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Tirzepatide may be the better choice if You have aggressive weight loss goals (15-25% of body weight)

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Mice were double- or single-housed and unless otherwise indicated fed ad libitum with either a regular chow (1314, Altromin or 5L0D, LabDiet) or HFD (58% fat, D12331, Research Diets) under constant ambient conditions of 22 2 C with constant humidity (4565%) and a 12 h:12 h light:dark cycle