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Acute kidney injury: Particularly in patients with pre-existing kidney impairment or severe volume depletion from GI side effects

Conversely, higher body weight may require the full dose escalation to achieve meaningful results

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"We found that semaglutide was effective in improving time spent in the target blood sugar range and reduction in body weight compared to placebo group," said Viral Shah, MD, lead study author and IU School of Medicine professor of medicine