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Phase 2 trial data showed retatrutide was generally well-tolerated, with a safety profile similar to other GLP-1 medications (semaglutide, tirzepatide)

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Because NNMT consumes nicotinamide, its inhibition theoretically increases the availability of nicotinamide for entry into the NAD + salvage pathway via nicotinamide phosphoribosyltransferase (NAMPT)