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The brain of a smoker becomes dependent on nicotine to produce endorphins, which pushes the smoker to smoke more in order to regain that feeling of well-being

[DOI] [PubMed] [Google Scholar] 106.Widlansky ME, Gutterman DD

Hallmark gene set analysis reveals pathways associated with interferon-alpha responses and DNA damage repair are downregulated while pathways associated with sterile inflammation are upregulated in NHBECs after DA vapor exposure To further characterize transcriptional profiles, we applied the pre-ranked GSEA to 50 Hallmark gene sets with well-defined biological mechanisms and coherent expression levels

Reynolds Vapor Company (Reynolds Vapor), an operating company of Reynolds American Inc