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For purposes of this paragraph (b)(5), the weighting applicable to any category of medical/surgical benefits is determined in the manner set forth in paragraph (b)(4) of this section for determining one-third or two-thirds of all medical/surgical benefits

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As randomized controlled experiments addressing the research questions are unavailable, naturalistic experiments comparing smoking in communities with restrictive e-cigarette use policies for youth (e.g., restrictions against sales to minors) compared with those with permissive youth policies (e.g., no sales restrictions) were considered to provide indirect evidence of the causal effect

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